We' ve shown for the first time that gene expression pattern is altered in the myocardium of cholesterol-fed mouse in response to ischemic preconditioning. This effect is apparent in the regulation of NO signaling, oxidant producing enzymes, and the mevalonate pathway. Our was the first demonstration in human apoB-100 transgenic mice, that hypercholesterolemia but not hypertriglyceridemia is responsible for the hyperlipidemia-induced, peroxynitrite-mediated cardiac dysfunction, and that increased cardiac NADPH oxidase activity is a major source of increased oxidative stress in...
We' ve shown for the first time that gene expression pattern is altered in the myocardium of cholesterol-fed mouse in response to ischemic preconditio...
