Betaine is widely distributed in plants and animals and has a role as an osmolyte and as a cofactor in methylation in liver metabolism. It has been shown to protect internal organs, improve vascular risk factors and enhance performance. The growing body of evidence shows that betaine is an important nutrient for the prevention of chronic disease. This volume surveys the current state of play in these and other areas of interest, including its role in one-carbon metabolism, tissue biochemistry and interactions with folate and other biomolecules. The analysis of betaines using different...