Our prime objective is to prepare a series of copper complex compounds which possess enhance biological activity by introducing 4-hydroxycoumarins and fluoroquinolones segments together. In the present article, we have synthesized twelve novel ligands and their Cu (II) complexes. We have focused much on antimicrobial activity, antioxidant and antitubarcular activity. Results from antimicrobial activity revealed that Cu (II) complexes were found biologically active as compared to its ligands. Few of the complexes have been found more potent antimicrobial agent against gram positive bacteria....