Different N-substituted sulfonamides were synthesized by reacting 4-Chloro-benzenesulfonyl chloride with 2-Methoxy aniline and 2-Ethyl-6-methyl aniline to form 4-chloro-N-(2-methoxyphenyl)benzenesulfonamide and 4-chloro-N-(2-ethyl-6-methylphenyl)benzene-sulfonamide respectively. Different N-substituted alkyl/aryl derivatives were synthesized using 4-chloro-N-(2-methoxyphenyl)benzenesulfonamide and 4-chloro-N-(2-ethyl-6-methylphenyl)benzenesulfonamide to yield 4-chloro-N-ethyl-N-(2-methoxylphenyl) benzenesulfonamide, N-benzyl-4-chloro-N-(2-methoxyphenyl) benzenesulfonamide,...

A facile method has been implemented for the synthesis of different N-substituted sulfamoylacetamides (3a-q) by the reaction of 4-acetamidobenzenesulfonyl chloride with a series of different alkyl/aralkyl/aryl amines in aqueous alkaline media under dynamic control of pH at 9-10. The structures of the synthesized N-substituted sulfamoylacetamides were elucidated through spectral analysis like FT-IR, EIMS and 1H-NMR. The synthesized derivatives were further screened against Chymotrypsin enzyme. The results revealed that most of the synthesized compounds were found to be potent chymotrypsin...