This book deals with advanced methods for complex phase I and phase I/II dose-finding clinical trials with multiple drugs and outcomes in oncology. It provides not only methodological aspects of the dose-finding methods, but also software implementations and practical considerations in applying these complex methods to real cancer clinical trials. Thus, the book aims to furnish researchers in biostatistics and statistical science with a good summary of recent developments of complex dose-finding methods as well as providing practitioners in biostatistics and clinical investigators with...