Critical limb ischemia is associated with high rates of limb loss & mortality. Within 6 months of presentation with CLI, 25% of patients will require major amputation. An estimated 250,000 major amputations are performed annually in the United States & Europe, resulting in a significant socioeconomic burden & reduction in quality of life indicators. Published rates of mortality for CLI approach 25% at 1 year & >50% at 5 years. Among revascularization methods, surgical bypass has been regarded as the gold standard, with better anatomical and clinical durability. However, patients with CLI are...