In spite of the huge research efforts and respectable scientific achievements, there are still challenges regarding the use of commercial ASIC technologies in space and safety-critical applications. The most important challenges are: 1. Radiation-hardened technologies are expensive (qualification and quality requirements are severe) and commercially not attractive (small volume production). 2. There is no standard integrated framework of circuit design techniques that provides simultaneous SEU, SET, and SEL fault-tolerance. 3. There is no standard design automation flow for fault-tolerant...