Parkinson's disease (PD) is a chronic neurological disorder which characterized by loss of nigrostriatal dopaminergic neurons. Current drugs only provide symptomatic relief and manage the stop the death of dopaminergic neurons. Developments of therapies for neurological diseases are limited and complex. The many case of PD are sporadic, genes mutation which associated with rare familial forms of the disease that code - synuclein, parking, DJ- 1, PINK - 1 and LRRK2. The relationship between UPS and neurodegeneration has been strengthened with the discovery of mutations in the gene that codes...