Biodegradable nanoparticles of insulin and Repaglinide were prepared by using biodegradable polymers and lipids. The prepared nanoparticles were evaluated by physicochemical parameters and in-vitro drug release. The optimized nanoparticle formulation of insulin and Repaglinide were loaded into Transdermal patch. These patches were subjected to release studies and preclinical evaluation parameters like bioavailability studies. Based on above studies, it was concluded that a single patch is suitable to control diabetes for more than 7 days

Buccoadhesive bilayer drug delivery Systems offers a simple and practical approach to achieve increased bioavailability, avoids first pass metabolism and to modify drug release profiles essential for controlled, site specific and localized drug action. Carvedilol used for the treatment of hypertension as buccal tablet can fasten the absorption by buccal region and bypass first pass metabolism. Thereby frequency of drug administration can be reduced and it can be economic for patients suffered by hypertension.