Vascular endothelial growth factor a 46 KD homodimeric glycoprotein is an endothelial - specific growth factor that is essential for angiogenesis Vascular endothelial growth factor stimulates interstitial collagenase production, Von Willebrand Factor release, and enhanced procoagulant activity. It induces permeability of fluids and proteins. It is 50,000 times more potent than histamine. Vascular endothelial growth factor is detectable in periodontal tissues within endothelial cells, plasma cells, macrophages and in junctional, sulcular and gingival epithelium.Diabetes mellitus is considered...