Radiation and bisphosphonate induced mandible osteonecrosis have distinct underlying physiopathological mechanisms, but both can constitute a serious problem and lead to functional impairment and facial disfigurement. The aims of treatment are the elimination of pain and associated infections, improvement of mouth function (opening, speech, mastication), and the prevention of deformity (fistulas, bone exposures, bone defects, pathological fractures). For patients with advanced refractory disease, pathological fracture, oro-cutaneous fistula and severe osteolysis, ressection associated with...
Radiation and bisphosphonate induced mandible osteonecrosis have distinct underlying physiopathological mechanisms, but both can constitute a serious ...