Myofibroblast are type of fibroblasts, which constitute a family of paracrine cells that play an important role in regulation of fundamental processes such as cell motility, proliferation,differentiation,apoptosis, morphogenesis,tissue repair,inflammation and immune response.In many organs like liver,lung and kidney they are primarily involved in fibrosis.In wound tissue they are implicated in wound contraction by intracellular contraction and concomitant alignment of collagen fibers.

Dental caries is an irreversible microbial disease of the calcified tissues of the teeth, characterized by demineralization of the inorganic portion and destruction of the organic matrix of the tooth which often leads to cavitation. Dental caries because of its uniqueness as a disease remains as one of man's most common, oldest and singly costliest ailment. There are practically no geographic areas in the world whose inhabitants do not exhibit some evidence of dental caries. The earliest detectable stage is the appearance of a white spot on the tooth. Caries is slowly progressing microbial...