In the present work, Different substituted derivatives of 5-substituted-1,3,4-oxadiazole-2-thiols were synthesized by successive conversions of 5-substituted carboxylic acids into respective ester, hydrazide and 1,3,4-oxadiazole. Finally the target compounds were obtained by reaction of 5-substituted-1,3,4-oxadiazole-2-thiols with a series of various electrophiles, in N, N-dimethyl formamide (DMF) in the presence of sodium hydride (NaH)which acts as a base. The structural characterization of these newly synthesized compounds was done by IR, 1H-NMR and EI-MS spectral data. All these compounds...
In the present work, Different substituted derivatives of 5-substituted-1,3,4-oxadiazole-2-thiols were synthesized by successive conversions of 5-subs...
The presented study encompasses the synthesis of a series of sulfonamides derivatives of 1-amino-2-phenylethane in excellent yield by reaction with various aryl sulfonyl chlorides, in the presence of aqueous sodium carbonate solution under dynamic pH control. These projected structures of the synthesized derivatives were characterized by IR, 1H-NMR and EIMS spectral techniques. Moreover, the screening of derivatives against acetyl cholinesterase (AChE), butyryl cholinesterase (BChE) and lipoxygenase (LOX) enzymes rendered these molecules as potent inhibitors of cholinesterase enzymes,...
The presented study encompasses the synthesis of a series of sulfonamides derivatives of 1-amino-2-phenylethane in excellent yield by reaction with va...
Sulfonamides are considered to be pharmaceutically important class of compounds. In the present work, N-(2,4-dimethylphenyl)-4-toluenesulfonamide was synthesized by the reaction of 2,4-dimethylaniline and 4-tosyl chloride (4-methylbenzenesulfonyl chloride) using 10% aqueous Na2CO3 solution as reaction medium. At the second step, the synthesized molecule was made to react with different alkyl/aralkyl halides to yield the target compounds, using N, N-dimethylformamide (DMF) as reaction medium and lithium hydride as an activator. The synthesis of all the compounds was verified by spectral...
Sulfonamides are considered to be pharmaceutically important class of compounds. In the present work, N-(2,4-dimethylphenyl)-4-toluenesulfonamide was ...
Different N-substituted sulfonamides were synthesized by reacting 4-Chloro-benzenesulfonyl chloride with 2-Methoxy aniline and 2-Ethyl-6-methyl aniline to form 4-chloro-N-(2-methoxyphenyl)benzenesulfonamide and 4-chloro-N-(2-ethyl-6-methylphenyl)benzene-sulfonamide respectively. Different N-substituted alkyl/aryl derivatives were synthesized using 4-chloro-N-(2-methoxyphenyl)benzenesulfonamide and 4-chloro-N-(2-ethyl-6-methylphenyl)benzenesulfonamide to yield 4-chloro-N-ethyl-N-(2-methoxylphenyl) benzenesulfonamide, N-benzyl-4-chloro-N-(2-methoxyphenyl) benzenesulfonamide,...
Different N-substituted sulfonamides were synthesized by reacting 4-Chloro-benzenesulfonyl chloride with 2-Methoxy aniline and 2-Ethyl-6-methyl anilin...
A facile method has been implemented for the synthesis of different N-substituted sulfamoylacetamides (3a-q) by the reaction of 4-acetamidobenzenesulfonyl chloride with a series of different alkyl/aralkyl/aryl amines in aqueous alkaline media under dynamic control of pH at 9-10. The structures of the synthesized N-substituted sulfamoylacetamides were elucidated through spectral analysis like FT-IR, EIMS and 1H-NMR. The synthesized derivatives were further screened against Chymotrypsin enzyme. The results revealed that most of the synthesized compounds were found to be potent chymotrypsin...
A facile method has been implemented for the synthesis of different N-substituted sulfamoylacetamides (3a-q) by the reaction of 4-acetamidobenzenesulf...
