In the present work, Different substituted derivatives of 5-substituted-1,3,4-oxadiazole-2-thiols were synthesized by successive conversions of 5-substituted carboxylic acids into respective ester, hydrazide and 1,3,4-oxadiazole. Finally the target compounds were obtained by reaction of 5-substituted-1,3,4-oxadiazole-2-thiols with a series of various electrophiles, in N, N-dimethyl formamide (DMF) in the presence of sodium hydride (NaH)which acts as a base. The structural characterization of these newly synthesized compounds was done by IR, 1H-NMR and EI-MS spectral data. All these compounds...

The presented study encompasses the synthesis of a series of sulfonamides derivatives of 1-amino-2-phenylethane in excellent yield by reaction with various aryl sulfonyl chlorides, in the presence of aqueous sodium carbonate solution under dynamic pH control. These projected structures of the synthesized derivatives were characterized by IR, 1H-NMR and EIMS spectral techniques. Moreover, the screening of derivatives against acetyl cholinesterase (AChE), butyryl cholinesterase (BChE) and lipoxygenase (LOX) enzymes rendered these molecules as potent inhibitors of cholinesterase enzymes,...

Sulfonamides are considered to be pharmaceutically important class of compounds. In the present work, N-(2,4-dimethylphenyl)-4-toluenesulfonamide was synthesized by the reaction of 2,4-dimethylaniline and 4-tosyl chloride (4-methylbenzenesulfonyl chloride) using 10% aqueous Na2CO3 solution as reaction medium. At the second step, the synthesized molecule was made to react with different alkyl/aralkyl halides to yield the target compounds, using N, N-dimethylformamide (DMF) as reaction medium and lithium hydride as an activator. The synthesis of all the compounds was verified by spectral...