In recent decades, a large number of reports related to the synthesis of N, O and S containing heterocycles have appeared owing to a wide variety of their biological activity. The metal catalyzed synthesis of heterocycles is becoming an important and highly rewarding protocol in organic synthesis. This book focuses on the use of metal as a catalyst for the synthesis of oxygen containing six-membered heterocylces. It describes the formation of different types of heterocyclic rings.

This book describes the incorporation of 2- 4'-oxadiazolo, imidazo, benzimidazo, thiadiazolo, isoxazolo, and pyrazolo] derivatives on to the 1,4-benzodiazepine nucleus through phenoxyl/ phenylamino spacer from the corresponding amidine, imidate ester, thiosemicarazone, dimethylaminomethylene ketone, and chalcone derivatives. The structures of all compounds have been established by elemental analysis, IR, 1H NMR, 13C NMR, and MS spectral data.

This book describes the synthesis of six-membered pyrimidine ring incorporated analogues from the intermediates amidine, dimethylaminomethylene ketone, chalcone, and chloro derivatives of 1,4-benzodiazepines following the strategies depicted in schemes 4.13-4.21 respectively. The structures of all compounds have been established by their elemental analysis, IR, 1H NMR, 13C NMR, and MS spectral data.

This book describes the synthesis of 2-(phenoxyl-4)-4"-1,5-benzodiazepino, 1,5-benzothiazepino, and 1,5-benzoxazepino incorporated analogues of 1,4-benzodiazepines 5.104-5.109 from the corresponding dimethylaminomethylene ketone and chalcone derivatives 5.099-5.103 following the strategies depicted in schemes 5.29-5.34 respectively. The structures of all compounds have been established by elemental analysis, IR, 1H NMR, 13C NMR, and MS spectral data.

This book describes the synthesis of amidines and imidate esters from 2-oxy/amino-4'-benzonitrile, thiosemicarbazone from 2-oxy-4'-benzaldehyde, dimethylaminomethylene ketone and chalcone from 2-oxy-4'-acetylphenyl derivatives of 1,4-benzodiazepine (2.094-2.100). The structures of all compounds have been established by elemental analysis (Carbon, Hydrogen, Nitrogen and Sulfur), IR, 1H NMR, and Mass spectral data.

This book includes two chapters. First chapter (chapter 1A) is concerned with the importance of MW assisted green chemistry approach in organic synthesis and second chapter (chapter 1B) included the importance of 1,4-benzodiazepines in drug design and synthesis. The enormous amount of research work that has been conducted in the pharmaceutical laboratories on these compounds during the last few decades derives its inspiration from the discovery of psychopharmacological properties of 1,4-benzodiazepines and their oxoderivatives.