Liver damage, including hepatitis, that is induced by chemicals or viruses often leads to liver fibrosis and sometimes leads to subsequent liver cirrhosis. For severe liver-associated diseases such as cirrhosis, liver transplantation is one of the most effective treatments. However, due to the shortage in donated organs and the growing list of patients in need of such intervention, transplantation is often not common.Stem cells and their possible use in cell therapy have drawn much attention recently, due to their potential for self-renewal and differentiation. Mesenchymal stem cells in vitro...

Alzheimer's disease (AD) is the most common cause of dementia in the elderly and is characterized by a progressive memory decline, impairments in language and visual spatial skills, impairments in behavior, resulting in a loss of independence, reduction of quality of life, and ultimately death. In the present study, we have described a facile synthesis of novel promising anti-Alzheimer's disease steroidal curcumin derivatives and investigated the importance of incorporating heterocylic moiety to the curcumin nucleus to form new effective hybrid molecules All the tested compounds have been...