The treatment of H. pylori remains a challenging clinical problem despite extensive research over the last 25 years. Levofloxacin (LVF) is safe and effective in first, second, and third line H. pylori eradication. Eradication rates were over 90% for the LVF based therapy. Conventional tablets or capsules have insufficient gastric residence time to treat H. pylori. Recently, gastroretentive systems for treating H. pylori have shown special interest. The prolongation of the local availability of the antibacterial agents has been reported to be an important factor to increase the effectiveness...

Local intra-pocket drug delivery devices can provide an effective concentration of the antimicrobial agent at the site of action with avoidance of undesirable side effects. This study explored the application of tetracycline HCl (Tc HCl) films based on gel forming polymers as drug release regulators for local treatment of periodontal pockets. Different film formulations were simply prepared by "solvent casting technique." Films were suitable for intra-pocket application, they were hard enough to be easily inserted into the periodontal pocket. Immediately after application, they hydrate by the...