Controlling Giardiasis outbreaks can be accomplished by early diagnosis. Recentally, ELISA has been considered as cost effective diagnostic method which can detect small quantities of coproantigens of parasite, even in mild infections, and diagnosed even if the live parasite is absent in the fecal samples. It can detect different soluble antigens dispersed in fecal matter rather than detecting cysts, trophozoites, or antigens on the surfaces of these morphologic forms.

This study aims to test the action of three different compounds acting as CP inhibitors (CPIs) namely fluromethylketone (FMK), vinyl sulfone (VS) and sodium nitro prussid (SNP). These specific irreversible inhibitors of CPs inhibit the degradation of hemoglobin (Hb) in developing schistosomula, eventually resulting in worm death and reduce egg production. These inhibitors may recently used as new chemotherapeutic drugs for treatment of schistosomiasis. This work trial to study the possible additive or synergistic effect of both PZQ and these CPIs on susceptible strains of S. mansoni infected...