Exposure to stress is always accompanied with elevated corticosterone synthesis and secretion. Elevation of corticosterone is essential for initiation of adaptive physiological alteration in the body system. However, prolonged elevated corticosterone in plasma as well as tissue incurs disruptive damage causing mal-adaptation to stressors. This biphasic response of corticosterone depends on types, intensity and duration of stress exposure. Hypobaric hypoxia, a low pressure oxygen condition unique to high altitude region is such a stressor. Mal-adaptation to high altitude causes acute mountain...