Hematological malignancies are associated with hematopoietic cells that have lost the capacity to differentiate normally to mature blood cells. Intreleukin-18 (IL-8) and matrix metalloproteinases 2 (MMP-2) might be involved in the proliferation of certain leukemic cells, tumor growth and metastasis. A prognostic factor is defined as a clinical measurement that could be predicted by response to treatment associated with overall survival. Determination of prognostic factors is especially important in malignant patients. We aim to investigate the expression of IL-8 and MMP-2 in various...
Hematological malignancies are associated with hematopoietic cells that have lost the capacity to differentiate normally to mature blood cells. Intrel...
The incidence of Crohns disease (CD) and ulcerative colitis (UC) is increasing, but differentiating between them is often difficult. Anti- Saccharomyces cerevisiae mannan antibodies (ASCA), perinuclear antineutrophil cytoplasmic antibodies (pANCA), pancreatic (PAB) and goblet cell autoantibodies (GAB) are serological markers associated with inflammatory bowel disease (IBD). The clinical significance and diagnostic value of these markers are not well defined in different populations.Determining the prevalence of these serological markers in Egyptian population with IBD and assessing the value...
The incidence of Crohns disease (CD) and ulcerative colitis (UC) is increasing, but differentiating between them is often difficult. Anti- Saccharomyc...
Immunomodulatory imbalance is the characteristic feature of autoimmune diseases like rheumatoid arthritis (RA). T helper (Th) 17 plays a critical role in the pathogenesis of RA. The balance of Th1 and Th17 is important for normal immune response. In RA therapy, methotrexate (MTX) has an important use depending on its anti-inflammatory effects, however, is limited due to its side effects. Curcumin is a natural plant product used as an immunomodulator. The aim of this study was to investigate the impact of curcumin and MTX administration singly or combined on a rat model with collagen-induced...
Immunomodulatory imbalance is the characteristic feature of autoimmune diseases like rheumatoid arthritis (RA). T helper (Th) 17 plays a critical role...
Thrombosis is a major mechanism of cardiovascular disease and is a leading cause of death. Thrombosis generally occurs in the setting of imbalance in haemostatic regulation favoring blood clot formation. Activated protein C (APC) is a naturally circulating anticoagulant protein in plasma, which exerts its effects mainly by breaking down activated factor V in the coagulation cascade. A single point mutation in the coagulation factor V gene (FV R506Q) renders factor V resistant to inactivation by APC. The frequency of this mutation is known to be significantly increased in patients with...
Thrombosis is a major mechanism of cardiovascular disease and is a leading cause of death. Thrombosis generally occurs in the setting of imbalance in ...
The diagnosis and assessment of the disease activity is the first step of treatment. It is of vital importance to find new markers that may be more indicative to the disease progression thus, planning a treatment regime that would be more effective. In case of viral hepatitis the most used parameters are PCR tests which is very expansive in addition to ALT level which reflects the viral infection effect on liver cells, whereas for SLE, assessment of ANA and antidsDNA are used. As for renal disease the most frequent assays are measuring the levels of urea and creatinine in the serum.Evidently...
The diagnosis and assessment of the disease activity is the first step of treatment. It is of vital importance to find new markers that may be more in...
