This comprehensive volume discusses the protease A13, summarizing the current status of basic and clinical research. Comprised of eight chapters, ADAMTS-13: Biology and Disease begins with an exploration of the biochemistry and structure-function relationships of A13 as well as its normal function in hemostasis (cleavage of von Willebrand factor). Emerging research themes for A13 are covered, including its potential role in angiogenesis and other aspects of cell biology. Clinical topics include laboratory assays for A13, inherited A13 deficiency, and acquired A13 deficiency. A chapter on...