A study was carried out in Maipokhari areas of Illam district in the Eastern Nepal where Swertia chirayita cultivation is common between 1800 to 2200masl. Cultivated chirayito showed high density and high productivity too. Bitter principle test showed the high value in chirayito collected from wild than cultivated site. However, students t-test showed no significance difference in bitter principle between wild and cultivated chirayito. In wild stage, the value of soil parameters is high as compared to cultivated sites so yield high bitterness. Over ninety percent of the local people are...