A high resolution spectral domain optical coherence tomography (SD-OCT) system was used to study in-vivo early morphological changes and optical nerve head (ONH) blood flow in Long Evans rat retina, induced by injection of sodium iodate (NaIO3). OCT images were acquired at the same retinal location from healthy rats and from rats at 1, 3, 6 12, 24, 72 and 168 hours post drug administration. Morphological OCT images showed the formation of a new low reflective layer between photoreceptor OS and RPE in all tested rats which was most likely fluid accumulation. A Doppler Optical Micro-Angiography...