Gene therapy comprises of introducing specific genetic material into target cells without producing toxic effects on surrounding tissue. Gene therapy is one of the recent advances in this field to deal with this obstacle with promising prospects. As an oral physician it is our responsibility to treat common oral premalignant lesions and conditions like leukoplakia and oral submucous fibrosis which have a definite malignant potential if timely and early diagnosis and treatment is not provided. Treatment options for recurrent or refractory oral cancers are limited. A Medline search was done...