Quinazolines are the derivatives of benzopyrimidine ring system. It is known and well documented in the literature that there exists a connection between wide spectrums of biological activities with the molecules having quinazoline moiety . Hence quinazoline-4(3H)-one is a lead compound for designing potential bioactive agents. Quinazoline derivatives possess a variety of activities like antibacterial, antifungal, anti-HIV , anthelmintic , CNS depressant and antitubercular . Synthesis of naturally occurring bioactive alkaloid having quinazolone system, vascinone is reported recently ....