A Beast Reborn continues Erika Lorenz' story after the death of Bill Draig. Erika struggles to cope with the massacre just a few months in the past. Before she is able to regain herself, the U.S. Congress revokes The Infected of their human rights and demands a purge of the vampire disease by military force. To add to the chaos, Constantine returns with a new army and seeks revenge on the city of Shelton. Even with the help of some mysterious outsiders and a human group known as The Slayers, the outlook is bleak. Erika and her friends are in the fight for their lives.