The present study serve to extend the growing number of earlier investigations on therapeutic products from freshwater and marine sources as potent antineoplastic agents and confirm that both squid ink extract and freshwater mussel extract of C. aegyptiaca decreased lipid peroxidation, improved antioxidant status, and thereby act as a potential therapeutic complement in the treatment of different pathologies that may be related to an imbalance of the cellular oxidoreductive status associated with liver injury following tumor inoculation.

Freshwater snails are used as sensitive biomarkers of aquatic ecosystem pollution. The potential impacts of zinc oxide nanoparticles (ZnONPs) on aquatic ecosystems have attracted special attention due to their unique properties. The present investigation was designed to evaluate the possible mechanisms of ecotoxicological effects of ZnONPs on freshwater snail Biomphalaria alexandrina. ZnONPs showed molluscicidal activity against B. alexandrina snails, and the LC50 was 145 ug/ml.Exposure to ZnONPs (7 and 35 ug/ml) for three consecutive weeks significantly induced malondialdehyde and nitric...

Holothuria arenicola is the most important and abundant sea cucumber species in the Mediterranean Sea on the Egyptian coast. The problems associated with antifibrotic drugs are chronic administration, the reduced therapeutic effects and toxicity, so developing antifibrotics from natural products may reduce the risk of toxicity and maintain the therapeutic effectiveness when they used clinically. The therapeutic use of sea cucumbers for healing is established, where they used for joint pain, tendonitis and sprains. The present prospective study correlated the antifibrotic effect of HaE to its...

Based on the present study, it was concluded that Holothuria arenicola extract (HaE) may be a potential alternative for the treatment of gastric ulceration-induced by administration of indomethacin with cold stress. Moreover, the present results confirmed that HaE decreased lipid peroxidation, improved antioxidant status, activation of free radical scavenging enzymes, and restoration of the stomach architecture, thereby could be a good new treatment for gastric ulcer. The study also demonstrated that the combination of HaE and ranitidine (especially in the pre-treated group) compared to an...