Rheumatoid arthritis (RA) is a chronic inflammatory joint disorder in which people suffer from joint as well as neurobiological disorder. These patients take multiple drugs which opens the chances of drug interaction. Therefore this book deals with the in-vitro and in-vivo interaction studies of leflunomide (a leading DMARD to treat RA) with NSAIDs, essential & trace elements. For in-vitro studies, methods were developed & validated (via ICH guide lines)on UV-spectrophotometer and HPLC which were then applied for drug interaction study. Leflunomide-metals complexes were also synthesized and...
Rheumatoid arthritis (RA) is a chronic inflammatory joint disorder in which people suffer from joint as well as neurobiological disorder. These patien...