The most well-known type of neurodegenerative dementia is Alzheimer's disease (AD) in elderly, an age-dependent neurodegenerative disease, proceeds at stages from mild, moderate to severe and gradually destroys the brain. Advancing age, age related diseases such as cardiovascular disease, diabetes, obesity and cancer, head trauma and exposure to heavy metals such as Al, cupper, iron and zinc are the major cause for AD. The current study was designed to explore the potent role of Salvia triloba, Piper nigrum, Ruta graveolens and Pegenum harmala in management of neuroinflammatory insults...