The work presented concerns the preparation, characterization and biological evaluation of Cu(II) and Zn(II) complexes of Schiff bases derived from amoxycillin, cephalexin, sulphamethoxazole and trimethoprim, and salicylalde-hyde and pyridoxal. In these complexes an amino group available in the drug substances was allowed to react with salicylaldehyde and pyridoxal hydrochloride, separately, to obtain Schiff bases which were, subsequently, reacted with Cu(CH3COO)2. H2O and/or Zn(CH3COO)2.2H2O to form Schiff base metal complexes. The ligands and the complexes were characterized by...