A simple and sensitive spectrophotometric method has been developed for the determination of clarithromycin in pure and commercial pharmaceutical formulations. The method involves formation of colored ion-associate complex of clarithromycin with bromothymol blue in acidic media (acetate buffer solution). The colored complex was extracted in chloroform which showed the optimum wavelength at 420 nm. Various conditions such as wavelength, acetate buffer pH, acetate buffer volume, bromothymol blue solution concentration and bromothymol blue solution volume were investigated. At the optimum...