A specific, rapid, reliable and precise reversed phase ultra-performance liquid chromatographic method has been developed and validated for the simultaneous of tablet dosage form. The method was validated according to ICH guidelines and the acceptance criteria for accuracy, precision, linearity, specificity and system suitability were found to be under ICH limits.

Giving a brief account of methods of estimation of Drugs, followed by brief account of HPLC method, instrumentation, performance calculations and information related to proposed method. Another part of work is method validation which includes introduction, steps in validation, validation report and validation parameters for chromatographic methods. RP-HPLC method for the quantitative estimation of Antiviral drug. These methods are validated in terms of sensitivity, accuracy and precision and can be used for the routine determination of Antiviral drug, in bulk drug and Pharmaceutical...

Over the past two decades there has been a growing appreciation on the importance of circadian rhythms on GIT physiology and on disease states, together with the realization of the significance of the drug administration on resultant pharmacodynamic and pharmacokinetics parameters. The significance of these day-night variations has not been over looked from the drug delivery perspective and pharmaceutical scientists have displayed considerable ingenuity in development of time delayed drug delivery systems to address emerging Chronotherapeutic formulations. Pulsincap technique helps us to...