Organic matrix based slow release fertilizers (SRFs) appear to be a better alternative for eco-friendly and sustainable plant productivity and have many advantages over the conventional chemical fertilizers, organic manures or biofertilizers. The slow release fertilizers, SRF-II have shown the maximum retention capacity of nitrogen upto 50-days in comparison to soluble chemical fertilizers and no fertilizers which resulted in consistent availability of ammonium/nitrate to the plant and more synchronization with the growth rate of plant. The slow release fertilizers, SRF-II showed significant...

1,3,4-thiadiazole is one of the most potent heterocyclic containing carbonic anhydrase and antibacterial inhibitor from the natural and synthetic origin. It possessed potent anticonvulsant activity in wide range preclinical in vitro and in vivo models. Recently, various 1,3,4-thiadiazole derivatives have been synthesized and evaluated their anticonvulsant activity. This review is a demonstration to compile the medicinal chemistry, anticonvulsant screening and their structural activity relationship as well as pharmacophoric pattern of various synthesized 1,3,4-thiadiazole derivatives.