Glioblastoma (GBM) is the most common primary brain tumor and yields a poor prognosis despite current surgical, radiological and chemotherapeutic regimens. Recent studies have provided evidence that the presence of cancer stem cells (CSC) may be responsible for GBM regrowth, dissemination and resistance to therapy. Various genetic abnormalities have been observed in GBM, such as loss of PTEN and NF1, EGFR amplification, as well as p53 mutation, which may be involved in the regulation of CSCs in GBM. This book showed that a codon-specific p53 mutation is associated with the tumorigenesis of...
Glioblastoma (GBM) is the most common primary brain tumor and yields a poor prognosis despite current surgical, radiological and chemotherapeutic regi...
