As there is a need to combat human diseases, many drugs are being used in the medical field. Though these drugs control the disease, when used in higher doses they may be toxic to the genetic system of human beings. Antihypertensive drugs are the most widely prescribed medications in the world. The duration of the pharmacological treatment of hypertension may last for decades and, therefore, patients are exposed to prolonged contact with these drugs. Long-term treatments require documentation of long-term safety and efficacy, including sensitive indices of genotoxic damage. Important part of...