The aim of study was to Design and Evaluation of Miconazole Nitrate Microsponge for Sustained Release Topical Drug Delivery System by Quasi-Emulsion Solvent diffusion Method. The average size of microsponge formulation is less than 300um. So it has good patient compliance. Microsponge formulation has ability to improve bioavailability & solubility of poorly soluble drug. The Miconazole Nitrate microsponge were prepared by using Eudragit RS100 as a polymer, PVA as an emulsifying agent, TEC as a plasticizer, DCM and methanol used as solvent. Optimization of Microsponge was done by using Central...