Acinetobacter baumannii is one of the most important opportunistic pathogens described by Infectious Disease Society of America. Acinetobacter baumannii has emerged as a threat to soldiers wounded during military operations in Iraq and Afghanistan as well as isolated from natural resources. It causes pneumonia, urinary tract infections and respiratory infections. Carbapenems are the most effective -lactam antibiotics that are routinely prescribed by clinicians to the patients infected with Acinetobacter baumannii and other Gram negative bacteria. Emergence of resistant strains against...

Alzheimer's disease is one of the most common neurological disease which is characterized by the presence of -amyloid (A ) peptides and highly phosphorylated tau proteins in the brain. Study of AD became more reliable with the development of new advances both in the in-vivo (like PET, SPECT, MRI, MRP, FMR Imaging, NMR etc) and in-vitro (CD, FTIR, Dye Binding, TEM, STEM, STM, AFM, FRET etc.) methods. They are used in the study of pathogenesis and diagnosis of AD. Every method has its own advantages and limitations. In the present review, we have tried to explain the advancement of different...

Differential proteomics analysis became more important and reliable with the development of new advances both in the labeled (like DIGE, ICAT, iTRAQ, ICPL) as well as label-free methods used in the field of differential proteomics. Validation of differential proteomics results have been done by ELISA, western blotting, immunohistochemistry, RT-PCR and real time qPCR. Differential proteomics are successfully used in the diverse studies like biomarker discovery, agriculture, pathogenesis, drug resistance and organism adaptation at diverse environmental stress. Every proteomic methods have its...

Salmonella is a Gram-negative facultative intracellular anaerobe causing typhoid fever (enteric fever) in humans. Fluoroquinolones and carbapenems are the drug of choice against Salmonella. Emergence of resistance against these drugs makes Salmonella, a very lethal pathogen. Fluoroquinolone resistance mechanisms include target gene mutations, active efflux pump, decreased outer membrane permeability and plasmid-mediated resistance. Recently, there is an emergence of beta-lactam resistance in the Salmonella which involve expression of beta-lactamases, presence of efflux pump, alterations in...