Throughout the ages, humans have relied on nature for their basic needs in terms of shelter, clothing, food, flavors and fragrances as not the least, medicines. In accordance with the recent interest in plant derived drugs and when taking into consideration that many of these drugs might be of phenolic, terpenoidal or alkaloidal nature, it becomes therefore a necessity to subject extracts of some promising medicinal plants to accurate and comprehensive bioassay guided chemical investigations. As a result of this intensive study, eleven phenolic compounds were individually isolated and...

Man ever since his first appearance on earth, has used plant throughout his historical development as a source of medicines. Medicinal plants have formed the basis of the folkloric medicine, which was the main source for new medical discoveries. By the middle of the nineteenth century at least 80% of all medicines were derived from plants. Therefore, in this work, as a result of this intensive study, seventeen phenolic constituents were individually isolated and identified from the methanolic extract of licorice roots by various chromatographic methods (TLC, CC, GC-MS, LC-MS, .. etc). The...

Pyridazine and pyrazole ring systems are known to possess potent biological and pharmacological properties. On the other hand some pyridazines derivatives are used as key starting material for the synthesis of commercial dyes. Acetylacetone, ethyl acetoacetate and malononitrile were coupled with diazotized arylamines to give arylazoacetylacetones, ethyl arylazoacetoacetates and arylazomalononitriles; these when refluxed with 5,6-diphenyl-2,3-dihydro-3-oxopyridazine-4-carbohydrazide, 3-amino-4,5-diphenyl-1H-pyrazolo 3,4-c]pyridazine and 3-hydrazino-4,5-diphenyl-1H-pyrazolo 3,4-c]pyridazine...