Dengue is a major public health concern throughout the tropical and sub-tropical regions of the world. It is the most rapidly spreading mosquito-borne viral disease, with a 30-fold increase in global incidence over the past 50 years. Infection with any of the Dengue virus serotypes can be asymptomatic, cause the classic dengue fever, or evolve to severe disease, which leads to hypovolemic shock and death if untreated. There is no approved specific treatment, prognostic markers, or vaccines for dengue, in part because there is insufficient knowledge of dengue pathogenesis. In this e-book, we...

Extensive loss of small bowel in all age groups has dramatic consequences on the lifestyle of the patient and the whole family and is accompanied by significant morbidity and mortality. All patients need nutritional and medical support and some of them remain dependent on long-term parenteral therapy. Recurrent surgical interventions or even intestinal transplantation may be necessary. However, the intestinal tract exhibits an astonishing ability to compensate for an extensive loss of small bowel. Adaptation to the new situation takes place with time by structural and functional changes...