This book evolved my understanding of proteins. They are actually sophisticated soft machines with specifically designed structures, and the design holds the mystery of life. The prion protein is a perfect example of such a design: replacing a few atoms of the protein can lead to dramatic and intriguing effects in the brain. While this phenomenon puzzled researchers for decades, molecular simulation opened a unique access to the mysterious design of proteins. It monitors the way the protein atoms move, interact and flex, even at any instance of time. With simulations we can "see" the...