The development of generalized sensitization during acute pain conditions plays an important potential role for the transition to and development of chronic pain. Such a phenomenon complicates adequate pain management and challenges current therapeutic modalities. This doctoral thesis aims to investigate the application of quantitative sensory testing in a clinical setting, mainly postoperative pain and chronic pain states. The pathophysiology, extent, and intensity of generalized sensitization, and in particular its relation to clinically relevant patient experiences, i.e. spontaneous pain...