Nitrogen containing synthetically and biologically important heterocyclic ring system namely pyrimidine have been reviewed. Based on review the pyrimidine derivatives will obtained by the various condensation methods. The structures of these compounds will evident by elemental analysis such as, IR, 1H NMR and mass spectral analysis. These biologically important pyrimidine and fused pyrimidine compounds will investigated for their antiinflammatory, antibacterial, antifungal and antiTB activities