Cancer is one of the fatal diseases and its early prognosis would be highly beneficial in curing it. CRP could be a profound tool in early diagnosis and prognosis. The present study proved that CRP levels are a consistent indicator of cancer risk than some tumor markers. In addition, CRP level show a strong association with risk of cancer incidence recurrence and death. The association between cancer incidence and CRP maybe tumor type specific.

Cattle industry is drastically affected by the trematode parasite Fasciola gigantica. This work aims to study the humoral and cellular immune responses to different F. gigantica antigens isolated from adult worm E/S product during the parasite invasion. This research is an attempt to find an effective vaccine against the parasite.Two Antigens were isolated and purified from excretory/secretory products as cysteine protease and fatty acids binding proteins (CP and FABP) of the parasite by immunoaffinity chromatography. From this study it was deduced that F. gigantica CP is a relevant candidate...

Innate immunity is thought to contribute to sustained virological response (SVR) to pgylated interferon- /ribavirin (peg-IFN- /ribavirin) therapy. Natural killer (NK) cells are implicated in the regulation of a protective immune response in patients chronically infected with HCV. We sought to investigate the level of NK subsets among Egyptian patients with chronic HCV and to analyze the influence of IFN therapy on this level. Samples were collected from chronically infected patients (n= 37) at baseline and from a subset before and after 6 months on peg-IFN- /ribavirin therapy. NK cells were...

During the early phases of a hepatitis C virus (HCV) infection, natural killer (NK) cells activation appears to be critical in the innate immune responses that have the potential of clearing the infection. Impaired activity of NK cells has been proposed as a mechanism contributing to viral persistence and chronic infection in HCV infection. We aim to assess the impact of HCV infections on NK cells regarding frequency, and subset distribution. The correlation between the phenotype of NK subsets and the various stages was assayed. Number of total NK cells was significantly reduced and a...

Artemether (ART), the methylated derivative of artemisinin, is an efficacious antimalarial drug that also displays antischistosomal properties. This study was designed to evaluate the therapeutic action of single intramuscular dose (50 mg/kg body weight) of ART on S. mansoni infected mice. The parasitological studies showed that maximum effect was reached when ART treatment interfered with 14 or 21 days old schistosomula. This was reported as reduction in worm burden and distribution, female worm fecundity, oogram patturn and tissue ova count. However, ART showed fewer effects on adult worms....

Schistosomiasis caused by Schistosoma (S.) mansoni is one of the major public health problems in the world including Egypt. Immunodiagnostic methods are more applicable for their better sensitivity and specificity than other methods. The detection of leucine aminopeptidase (LAP) in serum could be more valuable in diagnosis; hence early treatment could be applied before irreversible damage takes place. S. mansoni LAP antigen was purified from excretory/secretory (ES) products by DEAE-ion exchange chromatography and was injected into rabbits to raise specific polyclonal antibodies (pAb) which...

The diagnosis and assessment of the disease activity is the first step of treatment. It is of vital importance to find new markers that may be more indicative to the disease progression thus, planning a treatment regime that would be more effective. In case of viral hepatitis the most used parameters are PCR tests which is very expansive in addition to ALT level which reflects the viral infection effect on liver cells, whereas for SLE, assessment of ANA and antidsDNA are used. As for renal disease the most frequent assays are measuring the levels of urea and creatinine in the serum.Evidently...