Over the past two decades there has been a growing appreciation on the importance of circadian rhythms on GIT physiology and on disease states, together with the realization of the significance of time-of-day of drug administration on resultant pharmacodynamic and pharmacokinetic parameters. The significance of these day-night variation has not been overlooked from the drug delivery perspective and pharmaceutical scientist has displayed considerable intenuity in the development of time delayed drug delivery system to address emerging chronotherapeutic formulation. In the present study,...
Over the past two decades there has been a growing appreciation on the importance of circadian rhythms on GIT physiology and on disease states, togeth...
Rheumatoid arthritis (RA) is an autoimmune disease that results in a chronic, systemic inflammatory disorder that may affect many tissues and organs. It can be a disabling and painful condition, which can lead to substantial loss of functioning and mobility if not adequately treated. Naproxen is effective for the usual rheumatologic indications. But, the drug is practically insoluble at low pH and freely soluble at high pH. So, the drug release was controlled by formulating it into a sustained release matrix system with the help of hydrophilic polymers. The current work focuses on the...
Rheumatoid arthritis (RA) is an autoimmune disease that results in a chronic, systemic inflammatory disorder that may affect many tissues and organs. ...