Heterocyclic compounds have great applicability in pharmaceutics because they have specific chemical reactivity and provides false synthons in biosynthetic process or block the normal functioning of biological receptors. Important drugs, poisons and medicines (both natural and synthetic) such as sulphathiazole, pyrenthrin, rotenmone, alpidem, zolpidem, fluconazole, strychnine, reserpine, certain of the antihistamines, the ergot alkaloids caffeine, cocaine, barbiturates, etc. are heterocyclic compounds. Thiazolidinone moiety possesses several biological activities and it is essential precursor...
Heterocyclic compounds have great applicability in pharmaceutics because they have specific chemical reactivity and provides false synthons in biosynt...
The entire pharma industry is faced with the confront of growing productivity and novelty. The major hurdles are the increasing costs of research and development and a simultaneous stagnating number of new chemical entities. Taking in view of the applicability of heterocyclic compounds, in the present work several entities containing heterocyclic nucleus have been selected.Combinatorial and parallel chemistry are powerful tools for medicinal chemists in drug detection programs. It has expectant chemists to work out synthetic strategies and approaches that can be used for the construction of...
The entire pharma industry is faced with the confront of growing productivity and novelty. The major hurdles are the increasing costs of research and ...
Pyrimidine is a well known heterocyclic compound, which has been subjected to a large variety of structural modification in order to synthesize derivatives with different biological properties. Pyrimidine derivatives have been reported to possess a broad spectrum of pharmacological properties. Pyrimidine is the most important member of all the diazines as this ring system occurs widely in living organisms. Purines, uric acid, barbituric acid and some anti-malarial and anti-bacterial agents also contain the pyrimidine ring.
Pyrimidine is a well known heterocyclic compound, which has been subjected to a large variety of structural modification in order to synthesize deriva...
Compounds containing an azomethine group (-CH=N-) are known as Schiff bases and they are usually formed by the condensation of a primary amine with a carbonyl compound. Azomethines compounds are contain -C=N- group. These compounds are also known as imines or anils but most commonly, they are known as Schiff bases to honor Hugo Schiff1, who synthesized these compounds first, They are well known intermediate for the preparation of azetidinone2, thiazolidinone3 etc. Approximately thirty elements are essential to life As might be expected, the elemental components of proteins, carbohydrates and...
Compounds containing an azomethine group (-CH=N-) are known as Schiff bases and they are usually formed by the condensation of a primary amine with a ...
Generally pyrimidine derivatives such as 2-hydroxy-substitutedpyrimidine, 2-mercapto-substituted-pyrimidine and 2-amino-substituted pyrimidine are studied. Pyrimidines have been isolated from the nucleic acid hydrolysates. Pyrimidines are among those molecules that make life possible, have been some of the building blocks of DNA and RNA. Several analogues of pyrimidines have been used as compounds that interfere with the synthesis and functioning of nucleic acids e.g. fluorouracil, which has been used in cancer treatment. Modifications in the base, sugar and phosphate moieties of...
Generally pyrimidine derivatives such as 2-hydroxy-substitutedpyrimidine, 2-mercapto-substituted-pyrimidine and 2-amino-substituted pyrimidine are stu...
The actions of many infectious diseases are demanding due to fighting to antimicrobial agents. The emergence of fighting among bacteria to a wide variety of structurally unrelated antibacterial agents such as 6-lactams, macrolides, tetracyclines and fluoroquinolones as well as selected dyes and disinfectants has become a serious public health concern so makes it necessary to continue the search for new antibacterial agents. In recent scenario heterocycles is the different rule in drug synthesis. In that respect pyrimidine plays a significant rule among other heterocycles. From the literature...
The actions of many infectious diseases are demanding due to fighting to antimicrobial agents. The emergence of fighting among bacteria to a wide vari...
