Regeneration guarantees the resolution of a number of persuasive clinical problems in dentistry that have not been effectively managed through the use of various treatment modalities. The challenge is to create an environment with the optimal combination of matrix, cells, and soluble regulators for effective regenerative therapy. The scope of regeneration may be increased to include the replacement of periapical tissues, periodontal ligaments, gingival tissue, and even whole teeth. This would give patients a clear alternative to the artificial tooth implants that are currently available....