Worldwide mortality and morbidity from infectious diseases is being replaced by chronic diseases, such as cancer, obesity and type II diabetes, cardiovascular diseases, neurodegenerative diseases and aging which involve inflammation. Vascular endothelial growth factor (VEGF) as a potent pro-inflammatory cytokine is elevated in many human diseases, or animal models of human disease, which are mentioned above. Compounds derived from botanic sources, such as polyphenolic compounds, have shown anti-inflammatory activity. These natural compounds express anti-inflammatory activity by modulation of...