The evolution of the science and technology of niosomes as a drug carrier has passed through a number of distinct phases. Opinions of usefulness of these vesicles in drug delivery applications range from unsubstantial optimism to undeserved pessimism. The current deepening and widening of interest in niosomes speculates optimistically about some future applications of these non-ionic surfactant vesicles. The purpose of writing this review on niosomes as drug delivery vehicles was to compile the recent literature with special focus on their applications in drug delivery.