A novel, rapid and cost-effective chlorpromazine hydrochloride (CPZH) decolorization assay is described for the screening of antioxidant activity. A chromogenic reaction between CPZH and potassium persulfate at low pH produces an reddish-pink radical cation with maximum absorption at 527 nm in its first-order derivative spectrum. The antioxidant capacity of standard solutions of an antioxidant was evaluated by comparing with the inhibition curve using Trolox as the standard. Comparison of antioxidant capacity determined with this newly developed CPZH assay and with the well-known 2,2'-...

During the era of 1935-1945 the sulfonamide provided exceptional advances in the control of infectious diseases, particularly for these three major diseases hemolytic streptococcal infections, gonorrhea and other like pneumococcal pneumonia and meningitis etc. They also proved effective in urinary tract infections. As a therapeutic agent sulfonamides were succeeded as an antibiotic. After this it showed broad control of such infection like tuberculosis, staphylococcal sepsis, rickettsia disease, and infections due to other gram negative bacteria.

Beta lactam derivatives exhibit a range of bioactivities, including anti-angiogenic, anti-tumour, anti-malarial, anti-inflammatory and analgesic, anti-tubercular, anti-glaucoma, anti-HIV, cytotoxic and antimicrobial properties. The synthesis of metal complexes of lactam derivatives had received much attention due to the fact that they are among the first effective chemotherapeutic agents to be employed for the prevention and cure of bacterial infection in humans. The pharmacological activity of these types of molecules is often enhanced by complexation with metal ions.Certain theories had...