Potassium (K+) channels are tetrameric membrane proteins that play a critical role in diverse life-sustaining processes, e.g., the action potential. Their clinical significance is underscored by the observation that they are likely the founding members of the voltage-gated ion channel superfamily that includes sodium and calcium channels. The research aimed to address the gaps in our current understanding of K+ channel biology. The themes were as follows: classification of genome-complement of K+ channels; analysis of intrasubunit heterodomain co-evolution; sequence determinants of...